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Main Publication List

2022
  • Maruyama, T. and Fujita, Y. (2022) Cell competition in vertebrates — a key machinery for tissue homeostasis. Current Opinion in Genetics & Development, 72:15-21. [Pubmed]
  • Shirai, T., Sekai, M., Kozawa, K., Sato, N., Tanimura, N., Kon, S., Matsumoto, T., Murakami, T., Ito, S., Tilston-Lunel, A., Varelas, X., Fujita, Y. (2022) Basal extrusion of single-oncogenic mutant cells induces dome-like structures with altered microenvironments. Cancer Science, 00:1-12. [Pubmed]
  • Kuromiya, K., Aoki, K., Ishibashi, K., Yotabun, M., Sekai, M., Tanimura, N., Iijima, S., Ishikawa, S., Kamasaki, T., Akieda, Y., Ishitani, T., Hayashi, T., Toda, S., Yokoyama, K., Lee, C.-G. Usami, I., Inoue, H., Takigawa, I., Gauquelin, E., Sugimura, K., Hino, N., and Fujita, Y. (2022) Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells. Cell Reports, 40(12):111078. [Pubmed]
  • Mori, Y., Shiratsuchi, N., Sato, S., Chaya, A., Tanimura, N., Ishikawa, S., Kato, M., Kameda, I., Kon, S., Haraoka, Y., Ishitani, T., and Fujita, Y. (2022) Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis. Current Biology, 32(10):2144-2159.[Pubmed]
2021
  • Kamasaki, T., Miyazaki, Y., Ishikawa, S., Hoshiba, K., Kuromiya, K., Tanimura, N., Mori, Y., Tsutsumi, M., Nemoto, T., Uehara, R., Suetsugu, S., Itoh, T., and Fujita, Y. (2021) FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells. iScience, 24(9), 102994. [Pubmed]
  • Kon, S. and Fujita, Y. (2021) Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis. Developmental Biology, 476, 112-116.[Pubmed]
  • Kohashi, K., Mori, Y., Narumi, R., Kozawa, K., Kamasaki, T., Ishikawa, S., Kajita, M., Kobayashi, R., Tamori, Y., and Fujita, Y. (2021) Sequential Oncogenic Mutations Influence Cell Competition. Current Biology, S0960-9822(21)00893-9 [Pubmed]
  • Kozawa,K., Sekai, M., Ohba, K., Ito, S., Sako, H., Maruyama, T., Kakeno, M., Shirai, T., Kuromiya, K., Kamasaki, T., Kohashi, K., Tanaka, S., Ishikawa, S., Sato, N., Asano, S., Suzuki, H., Tanimura, N., Mukai, Y., Gotoh, N., Tanino, M., Tanaka, S., Natsuga, K., Soga, T., Nakamura, T., Yabuta, Y., Saitou, M., Ito, T., Matsuura, K., Tsunoda, M., Kikumori, T., Iida, T., Mizutani, Y., Miyai, Y., Kaibuchi, K., Enomoto, A., and Fujita, Y. (2021) The CD44/COL17A1 Pathway Promotes the Formation of Multilayered, Transformed Epithelia. Current Biology, 31(14),3086-3097 [Pubmed]
2020
  • Maruyama, T., Sasaki, A., Iijima, S., Ayukawa, S., Goda, N., Tazuru, K., Hashimoto, N., Hayashi, H., Kozawa, K., Sato, N., Ishikawa, S., Morita, T., and Fujita, Y. (2020) ZAK inhibitor PLX4720 promotes extrusion of transformed cells via cell competition. iScience, 23, 101327.[Pubmed]
  • Takeuchi, Y., Narumi,R., Akiyama, R., Vitiello, E., Shirai, T., Tanimura, N., Kuromiya, K., Ishikawa, S., Kajita, M., Tada, M., Haraoka, Y., Akieda, Y., Ishitani, T., Fujioka, Y., Ohba, Y., Yamada, S., Hosokawa, Y., Toyama, Y., Matsui, T., and Fujita, Y. (2020) Calcium Wave Promotes Cell Extrusion. Current Biology, S0960-9822(19)31594-5.[Pubmed]
  • Sato, N., Yako, Y., Maruyama, T., Ishikawa, S., Kuromiya, K., Tokuoka, S.M., Kita, Y., and Fujita, Y. (2020) The COX-2/PGE2 pathway suppresses apical elimination of RasV12-transformed cells from epithelia. Communications Biology, 24;30(4):670-681. [Pubmed]
2019
  • Fujita, Y. (2019) Flower power as human cancer cells compete. Nature, 572 (7768): 181-182.[Pubmed]
  • Tanimura, N. and Fujita, Y. (2019) Epithelial defense against cancer (EDAC). Seminars in Cancer Biology, pii: S1044-579X(19)30033-1.[Pubmed]
2018
  • Takagi, M., Ikegawa, M., Shimada, T., Ishikawa, S., Kajita, M., Maruyama, T., Kamasaki, T. and Fujita, Y. (2018) Accumulation of the myosin-II-spectrin complex plays a positive role in apical extrusion of Src-transformed epithelial cells. Genes to Cells, 23(11):974-981.[Pubmed]
  • Yako, Y., Hayashi, T., Takeuchi, Y., Ishibashi, K., Kasai, N., Sato, N., Kuromiya, K., Ishikawa, S. and Fujita, Y. (2018) ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells. Scientific Reports, 25;8(1):9639.[Pubmed]
  • Watanabe, H., Ishibashi, K., Mano, H., Kitamoto, S., Sato, N., Hoshiba, K., Kato, M., Matsuzawa, F., Takeuchi, Y., Shirai, T., Ishikawa, S., Morioka, Y., Imagawa, T., Sakaguchi, K., Yonezawa, S., Kon, S., and Fujita, Y. (2018) Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells. Cell Reports, 26;23(13):3721-3729.[Pubmed]
  • Sasaki, A., Nagatake,T., Egami, R., Gu, G., Takigawa, I., Ikeda, W., Nakatani, T., Kunisawa, J. and Fujita, Y. (2018) Obesity suppresses cell competition-mediated apical elimination of RasV12-transformed cells from epithelial tissues. Cell Reports, 23(4):974-982.[Pubmed]
  • Kasai, N., Kadeer, A., Kajita, M., Saitoh, S., Ishikawa, S., Maruyama, T. and Fujita, Y. (2018) The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation. Scientific Reports, 8(1):2097.[Pubmed]
2017
  • Maruyama, K. and Fujita, Y. (2017) Cell competition in mammals; novel homeostatic machinery for embryonic development and cancer prevention. Current Opinion in Cell Biology, 15;48:106-112.[Pubmed]
  • Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J., Duchen, M. R., Nam, J.-M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T., and Fujita, Y. (2017) Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. Nature Cell Biology, 19(5):530-541.[Pubmed]
    Highlight in Nature Cell Biology 2017, 19(5), 414-5. 'Metabolic changes promote rejection of oncogenic cells.' [Pubmed] and Science Signaling 2017, 10 (478), eaan5866. 'Epithelial cells reject abnormal neighbors.' [Pubmed]
  • Kadeer, A., Maruyama, T., Kajita, M., Morita T., Sasaki, A., Ohoka, A., Ishikawa, S., Ikegawa, M., Shimada, T., and Fujita, Y. (2017) Plectin is a novel regulator for apical extrusion of RasV12-transformed cells. Scientific Reports, 7:44328. doi: 10.1038/srep44328.[Pubmed]
  • Saitoh, S., Maruyama, T., Yako, Y., Kajita, M., Fujioka, Y., Ohba, Y., Kasai, N., Sugama, N., Kon, S., Ishikawa, S., Hayashi, T., Yamazaki, T., Tada, M., and Fujita, Y. (2017) Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells. Proceedings of the National Academy of Sciences of the USA, 114 (12), E2327-E2336.[Pubmed]
2016
  • Yamamoto, S., Yako, Y., Fujioka, Y., Kajita, M., Kameyama, T., Kon, S., Ishikawa, S., Ohba, Y., Ohno, Y., Kihara, A., and Fujita, Y. (2016) A role of the sphingosine-1-phosphate (S1P)- S1P receptor 2 pathway in Epithelial Defense Against Cancer (EDAC). Molecular Biology of the Cell, 27(3):491-499. [Pubmed]
2015
  • Yamauchi, H., Matsumaru, T., Morita, T., Ishikawa, S., Maenaka, K., Takigawa, I., Semba, K., Kon, S. and Fujita, Y. (2015) The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia. Scientific Reports, 5:15336 doi:10.1038/srep15336. [Pubmed]
  • Ohoka, A., Kajita, M., Ikenouchi, J., Yako, Y., Kitamoto, S., Kon, S., Ikegawa, M., Shimada, T., Ishikawa, S., and Fujita, Y. (2015) EPLIN is a crucial regulator for extrusion of RasV12-transformed cells. Journal of Cell Science, 128, 781-789 doi:10.1242/jcs.163113. [Pubmed]
2014
  • Kajita, M., Sugimura, K., Ohoka, A., Burden, J., Suganuma, H., Ikegawa, M., Shimada, T., Kitamura, T., Shindoh, M., Ishikawa, S., Yamamoto, S., Saitoh, S., Yako, Y., Takahashi, R., Okajima, T., Kikuta, J., Maijima, Y., Ishii, M., Tada, M., and Fujita, Y. (2014) Filamin acts as a key regulator in epithelial defence against transformed cells. Nature Communications, 31 Jul; doi: 10.1038/ncomms5428. [Pubmed]
  • Anton, K. A., Sinclair, J., Ohoka, A., Kajita, M., Ishikawa, S., Benz, P. M., Renne, T., Balda, M., Jorgensen, C., Matter, K., and Fujita, Y. (2014) PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium. Journal of Cell Science, 127(16):3425-33. [Pubmed]
2012
  • Katoh, H and Fujita, Y. (2012) Epithelial homeostasis: elimination by live cell extrusion. Current Biology, 22 (11), R453-5. [Pubmed]
  • Yamauchi, H and Fujita, Y. (2012) Epithelial self-defense against cancer. Cell Research, 24 April 2012; doi: 10.1038/cr.2012.69. [Pubmed]
  • Norman, M, Wisniewska, K. A., Lawrenson, K., Garcia-Miranda G., Tada M., Kajita M., Mano, H., Ishikawa, S., Ikegawa, M., Shimada, T., and Fujita, Y. (2012) Loss of Scribble causes cell competition in mammalian cells. Journal of Cell Science, 125(1):59-66. [Pubmed]
    Highlight in Journal of Cell Science 2012 125:e101
2011
  • Fujita, Y. (2011) Interface between normal and transformed epithelial cells ―A road to a novel type of cancer prevention and treatment. Cancer Science, vol. 102 (10), p1749-1755 [Pubmed].
  • Hogan, C., Kajita, M., Lawrenson, K., and Fujita, Y. (2011) Interactions between normal and transformed epithelial cells: their contributions to tumourigenesis. Int J Biochem Cell Biol., 43(4):496-503. [Pubmed]
2010
2009
  • Hogan, C., Dupre'-Crochet, S., Norman, M., Kajita, M., Zimmermann, C., Pelling, A.E., Piddini, E., Baena-Lo'pez, L.A., Vincent, J. P., Hosoya, H., Itoh, Y., Pichaud, F. and Fujita, Y. (2009) Characterization of the interface between normal and transformed epithelial cells. Nature Cell Biology, 11 (4), 460-467. [Pubmed]
  • Figueroa, A., Kotani, H., Toda, Y., Mazan-Mamczarz, K., Mueller, E. C., Otto, A., Lena Disch, Mark Norman, Rasika M. Ramdasi, Keshtgar, M., Gorospe, M., and Fujita,Y. (2009) Novel roles of Hakai in cell proliferation and oncogenesis. Mol. Biol. Cell, 20: 3533-3542. [Pubmed]
2008
  • Ferber, E.C., Kajita, M., Wadlow, A., Tobiansky, L., Niessen, C., Ariga, H., Daniel, J. and Fujita, Y. (2008) A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus. J. Biol. Chem., 283 (19), 12691-12700. [Pubmed]
2007
  • Bialucha, CB, Ferber E.C., Pichaud F., Peak-Chew S.Y., and Fujita, Y. (2007) p32 is a novel mammalian Lgl-binding protein that enhances the activity of protein kinase Cζ and regulates cell polarity. Journal of Cell Biology, 178(4), 575-581. [Pubmed]
  • Hosking, RC, Ulloa, F., Hogan, C., Figueroa, A., Gevaert, K., Birchmeier, W., Briscoe, J., and Fujita, Y. (2007) The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Molecular Biology of the Cell, 18, 1918-1927. [Pubmed]
  • Crochet, SD., Figueroa, A., Hogan, C., Ferber E., Bialucha, UC., Adams, J., Richardson, ECN., and Fujita, Y. (2007) Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts. Mol. Cell Biol., 27 (10), 3804-3816. [Pubmed]
2005
  • Fujita, Y., Hogan, C. and Braga, V.M.M. (2005) Regulation of cell-cell adhesion by Rap1. Methods in Enzymology, vol. 407, 359-372. [Pubmed]
2004
  • Fujita, Y. and Hogan, C. (2004) Adherens Junction. Encyclopedic Reference of Genomics and Proteomics (Springer).
  • Hogan, C., Serpente, N., Cogram, P., Hosking, C. R., Bialucha, C. U., Feller, S. M., Braga, V. M. M., Birchmeier, W., and Fujita, Y. (2004) Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol. Cell Biol., 24 (15), 6690-6700. [Pubmed]
2002
  • Fujita, Y., Krause, G., Scheffner, M., Zechner, D., Leddy, H. E. M., Behrens, J., Sommer, T., and Birchmeier, W. (2002) Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nature Cell Biology, 4, 222-231. [Pubmed]
1998
  • Fujita, Y., Shirataki, H., Sakisaka, T., Asakura, T., Ohya, T., Kotani, H., Yokoyama, S., Nishioka, H., Matsuura, Y., Mizoguchi, A., Scheller, R. H., and Takai, Y. (1998) Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron, 20, 905-915 [Pubmed]